Rapid evaluation of aminoglycosides ototoxicity using internal ear tissue culture.
نویسندگان
چکیده
منابع مشابه
[An in vitro rapid evaluation of drug-induced ototoxicity and of reductive effect of calcium on aminoglycoside ototoxicity using organ culture].
The ototoxicity of aminoglycoside and anticancer platinum drug was analysed using an organ culture system. The effect of calcium antagonism on aminoglycoside ototoxicity was investigated by the same system. The inner ears of mice, 16-day embryos, were cultured for 5 days with or without gentamicin (GM) or kanamycin (KM) or streptomycin (SM), or ribostamycin (RSM), including 1, 10, 100, or 1000 ...
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شناسایی مخاطرات در واحد 400 پالایشگاه گاز پارسیان. در این پروزه با بکارگیری از تکنیک hazop به شناسا یی مخاطرات ، انحرافات ممکن و در صورت لزوم ارایه راهکارهای مناسب جهت افزایش ایمنی فرا یند پرداخته میگردد. شرایط عملیاتی مخاطره آمیز نظیر فشار و دمای بالا و وجود ترکیبات مختلف سمی و قابل انفجار در واحدهای پالایش گاز، ضرورت توجه به موارد ایمنی در این چنین واحدهایی را مشخص می سازد. مطالعه hazop یک ر...
Ototoxicity of aminoglycosides correlated with their action on monomolecular films of polyphosphoinositides.
The ototoxicities of eight aminoglycoside antibiotics and fragments were measured quantitatively by cochlear perfusion in the guinea pig. Perilymphatic spaces were perfused for 1 hr with ‘artificial perilymph’ containing 10 mM drug, during which time continuous measurements of cochlear microphonic potentials were made. Kanamycin B and neomycin I3 caused the most rapid decline of cochlear microp...
متن کاملCisplatin ototoxicity blocks sensory regeneration in the avian inner ear.
Cisplatin is a chemotherapeutic agent that is widely used in the treatment of solid tumors. Ototoxicity is a common side effect of cisplatin therapy and often leads to permanent hearing loss. The sensory organs of the avian ear are able to regenerate hair cells after aminoglycoside ototoxicity. This regenerative response is mediated by supporting cells, which serve as precursors to replacement ...
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ژورنال
عنوان ژورنال: AUDIOLOGY JAPAN
سال: 1989
ISSN: 1883-7301,0303-8106
DOI: 10.4295/audiology.32.695